UBE2S interacting with TRIM28 in the nucleus accelerates cell cycle by ubiquitination of p27 to promote hepatocellular carcinoma development.
作者： Huijie Bian , Zhi-Nan Chen , Ding Wei , Yu-Le Yong , Hao Li
DOI: 10.1038/S41392-020-00432-Z
关键词: In vivo 、 Cell cycle 、 Biology 、 TRIM28 、 Somatic cell 、 Hepatocellular carcinoma 、 Gene 、 Metastasis 、 Mutation 、 Cancer research
摘要: … , FGF4, and FGF19) in cell cycle pathways during liver carcinogenesis, and these … therapies. However, identifying a key driver gene or mutation that can both participate in the cell cycle …
nature.com
scilit.net参考文章(43)
D Zhong, P Wan, L Dong, F Liu, X Wang, Y Wan, W Xiao, W W Zhang, J Wang, Y Zhang, J Hou, X Qian, H Zhang, Z Zhang, M Li, R Wang, K Liao, Y Wang, Z Li, Ube2s regulates Sox2 stability and mouse ES cell maintenance. Cell Death & Differentiation. ,vol. 23, pp. 393- 404 ,(2016) , 10.1038/CDD.2015.106
Zeng-Xin Qi, Jia-Jun Cai, Ling-Chao Chen, Qi Yue, Yan Gong, Yu Yao, Ying Mao, TRIM28 as an independent prognostic marker plays critical roles in glioma progression Journal of Neuro-oncology. ,vol. 126, pp. 19- 26 ,(2016) , 10.1007/S11060-015-1897-8
Carlos T. Pineda, Saumya Ramanathan, Klementina Fon Tacer, Jenny L. Weon, Malia B. Potts, Yi-Hung Ou, Michael A. White, Patrick Ryan Potts, Degradation of AMPK by a Cancer-Specific Ubiquitin Ligase Cell. ,vol. 160, pp. 715- 728 ,(2015) , 10.1016/J.CELL.2015.01.034
Cho-Rok Jung, Kyung-Sun Hwang, Jinsang Yoo, Won-Kyung Cho, Jin-Man Kim, Woo Ho Kim, Dong-Soo Im, E2-EPF UCP targets pVHL for degradation and associates with tumor growth and metastasis. Nature Medicine. ,vol. 12, pp. 809- 816 ,(2006) , 10.1038/NM1440
Hermann-Josef Meyer, Michael Rape, Enhanced protein degradation by branched ubiquitin chains Cell. ,vol. 157, pp. 910- 921 ,(2014) , 10.1016/J.CELL.2014.03.037
Donato Tedesco, Jianhuan Zhang, Lan Trinht, Guita Lalehzadeh, Rene Meisner, Ken D. Yamaguchi, Daniel L. Ruderman, Harald Dinter, Deborah A. Zajchowski, The Ubiquitin-Conjugating Enzyme E2-EPF Is Overexpressed in Primary Breast Cancer and Modulates Sensitivity to Topoisomerase II Inhibition Neoplasia. ,vol. 9, pp. 601- 613 ,(2007) , 10.1593/NEO.07385
Brenda A. Schulman, J. Wade Harper, Ubiquitin-like protein activation by E1 enzymes: the apex for downstream signalling pathways Nature Reviews Molecular Cell Biology. ,vol. 10, pp. 319- 331 ,(2009) , 10.1038/NRM2673
Takeshi Yokoe, Yuji Toiyama, Yoshinaga Okugawa, Koji Tanaka, Masaki Ohi, Yasuhiro Inoue, Yasuhiko Mohri, Chikao Miki, Masato Kusunoki, KAP1 is associated with peritoneal carcinomatosis in gastric cancer. Annals of Surgical Oncology. ,vol. 17, pp. 821- 828 ,(2010) , 10.1245/S10434-009-0795-8
Gabriel Schlenstedt, Protein import into the nucleus FEBS Letters. ,vol. 389, pp. 75- 79 ,(1996) , 10.1016/0014-5793(96)00583-2
Mathew J. Garnett, Jörg Mansfeld, Colin Godwin, Takahiro Matsusaka, Jiahua Wu, Paul Russell, Jonathon Pines, Ashok R. Venkitaraman, UBE2S elongates ubiquitin chains on APC/C substrates to promote mitotic exit Nature Cell Biology. ,vol. 11, pp. 1363- 1369 ,(2009) , 10.1038/NCB1983