Expression of myeloid antigens by blast cells in acute lymphoblastic leukemia of adults. The Southwest Oncology Group experience.

摘要: A subset of adult acute lymphoblastic leukemia (ALL) patients have blast cells which co-express myeloid-associated antigens (MY+ ALL). We analyzed 113 ALL cases for expression MY-associated (MAA). was diagnosed by standard morphology, cytochemistry, and immunophenotype in central review. MY+ when > or = 20% lymphoblasts co-expressed CD13 and/or CD33. Overall incidence 31/113 (27%). MAA not significantly correlated with WBC, count, hemoglobin, hematocrit. were more likely to express B-associated antigens, especially CALLA, be FAB L2, Ph+, the BCR-ABL translocation PCR, but these differences statistically significant. All induced a L10M regimen, 67 (59%) achieved CR: 43/66 (65%) B MY neg; 14/29 (48%) MY+; 10/16 (63%) T 0/2 MY+. In age-adjusted analyses CR rate did differ between neg B- T-cell patients. Of patients, 84 died remaining 29 been followed median 49 months. proportional hazards regression adjusting age heterogeneity survival among four groups significant (p 0.021), largely due status. The mortality 85% greater compared (two-tailed p 0.013). By contrast, vary data indicate that is useful predicting overall treated protocol. As predictive factor comparable WBC superior stratification markers this group