Budesonide/formoterol vs. salmeterol/fluticasone in COPD: a systematic review and adjusted indirect comparison of pneumonia in randomised controlled trials.

摘要: Summary Aims:  This analysis was designed to provide a comparison between budesonide/formoterol and salmeterol/fluticasone for the relative incidence of pneumonia adverse events, serious events pneumonia-related mortality in patients being treated chronic obstructive pulmonary disease. Methods:  An initial literature search revealed no suitable head-to-head trials therefore systematic review conducted find randomised controlled providing data input into an adjusted indirect two combination treatments using placebo as common comparator. The Bucher method used calculate odds ratios 95% confidence intervals. Results:  Eight four were identified relevant analyses. proportion experiencing event significantly lower with than (odds ratio, 0.47; interval, 0.28–0.80). also 0.41; 0.19–0.86). However, there too few draw any firm conclusions on mortality. Conclusions:  results support hypothesis that is associated fewer disease. limitations are from single study, TORCH, have large bearing overall findings analysis, heterogeneity length dosing included studies, although it does not appear affected reported results. Another important limitation lack predefined diagnostic standards these studies.