Prevalence of Genes of OXA-23 Carbapenemase and AdeABC Efflux Pump Associated with Multidrug Resistance of Acinetobacter baumannii Isolates in the ICU of a Comprehensive Hospital of Northwestern China.

摘要: The objective of this study was to explore the molecular epidemiology and genetic support clinical multidrug resistant (MDR) Acinetobacter baumannii (A. baumannii) isolates in an ICU ward a comprehensive hospital. A total 102 non-duplicate drug-resistant A. were identified 93 (91.1%) them MDR strains. Molecular analysis demonstrated that carbapenemase genes blaOXA-23 blaOXA-51 presented all (100%), but other genes, including blaOXA-24, blaOXA-58, blaIMP-1, blaIMP-4, blaSIM, blaVIM completely absent isolates. In addition, AdeABC efflux system detected 88.2% (90/102) Interestingly, addition pump inhibitor, reserpine could significantly enhance susceptibility moxifloxacin, cefotaxime, imipenem (p < 0.01). Clonal relationship further grouped these into nine clusters, strains mainly clusters A, B, C, D, which include 16, 13, 25, 15 isolates, respectively. This carrying carbapenemase-encoding are main prevalent baumannii, co-expression oxacillinase proteins thus considered be important reason for prevalence organism