Therapeutic angiogenesis for revascularization in peripheral artery disease.

摘要: Therapeutic angiogenesis for peripheral artery disease (PAD), achieved by gene and cell therapy, has recently raised a great deal of hope patients who cannot undergo standard revascularizing treatment. Although pre-clinical studies gave very promising data, still clinical trials therapy have not provided satisfactory results. On the other hand, approach, despite several limitations, demonstrated more beneficial effects but initial must be constantly validated larger randomized, multi-center, double-blinded, placebo-controlled trials. This review focuses on previous recent limb ischemia, including both experimental research, summarizes some important papers published in this field. Moreover, it provides short comment combined approach example heme oxygenase-1 overexpressing cells with therapeutic properties.