Protein Recognition in Drug-Induced DNA Alkylation: When the Moonlight Protein GAPDH Meets S23906-1/DNA Minor Groove Adducts
作者： Gaëlle Savreux-Lenglet , Sabine Depauw , Marie-Hélène David-Cordonnier
关键词: Biochemistry 、 HMG-box 、 DNA polymerase II 、 Biology 、 DNA adduct 、 Molecular biology 、 DNA damage 、 DNA Maintenance 、 Adductomics 、 DNA clamp 、 DNA Alkylation
摘要: DNA alkylating drugs have been used in clinics for more than seventy years. The diversity of their mechanism action (major/minor groove; mono-/bis-alkylation; intra-/inter-strand crosslinks; stabilization/destabilization, etc.) has undoubtedly major consequences on the cellular response to treatment. aim this review is highlight variety established protein recognition adducts then particularly focus glyceraldehyde-3-phosphate dehydrogenase (GAPDH) function adduct interaction with illustration using original experiments performed S23906-1/DNA adduct. introduction a state art protein/DNA recognition, depending or minor groove orientation bonding as well molecular terms double-stranded maintenance. It reviews implication proteins from both repair, transcription, replication and chromatin maintenance selective recognition. main section manuscript focusing moonlighting GAPDH model peculiar destabilizing drug S23906-1. S23906-1 large functions are presented prior direct binding adducts.
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