LC-MS in analytical toxicology: some practical considerations
作者： Lewis Couchman , Phillip E. Morgan
DOI: 10.1002/BMC.1566
关键词: Tandem mass spectrometry 、 Sample preparation 、 Analyte 、 Ionization 、 Chromatography 、 Chemistry 、 Matrix (chemical analysis) 、 Mass spectrometry 、 Analytical Toxicology 、 Liquid chromatography–mass spectrometry 、 Analytical chemistry 、 Clinical biochemistry 、 Biochemistry 、 Molecular biology 、 Pharmacology 、 Drug discovery 、 General Medicine
摘要: Liquid chromatography, coupled with single-stage or tandem mass spectrometry, is a powerful tool increasingly used in analytical toxicology. However, the atmospheric pressure ionization processes involved are complex, and subject to interference from matrix components, for example. Further, techniques sample preparation, chromatography analysis developing rapidly. An understanding of advantages limitations LC-MS ensures appropriate analyses performed, that reliable results generated. Consideration should be given influence preparation chromatographic conditions on analyte at spectrometer interface. This review aims provide some practical guidance examples aid method development commonly encountered analytes Copyright © 2010 John Wiley & Sons, Ltd.
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