Structural Distinctions among Acetylcholinesterase Forms

摘要: Acetylcholinesterase (EC 3.1.1.7) is associated primarily with cells involved in cholinergic synaptic transmission, but it also found a variety of other neuronal and few nonneuronal cells, like erythrocytes, which its function unclear (Nachmansohn, 1959). The catalytic properties acetylcholinesterase have been studied intensively for more than 40 years, details about specificity mechanism features that distinguish from the similar enzyme cholinesterase 3.1.1.8) can be many reviews (Froede Wilson, 1971; Rosenberry, 1975; Massoulie Bon, 1982). Although no role transmission has yet demonstrated, remarkable both these enzymes exist multiple forms striking structural parallels (see This review will focus on protein structures various relationship to cellular localization.