Adipocyte-derived factors in age-related dementia and their contribution to vascular and Alzheimer pathology.

摘要: Age-related dementia is increasingly recognized as having a mixed pathology, with contributions from both cerebrovascular factors and pathogenic associated Alzheimer's disease (AD). Furthermore, there accumulating evidence that vascular risk in midlife, e.g., obesity, diabetes, hypertension, increase the of developing late-life dementia. Since obesity changes body weight/adiposity often drive diabetes understanding relationship between adiposity age-related may reveal common underlying mechanisms. Here we offer brief appraisal how weight are related to AD on basis, examine involvement two key adipocyte-derived hormones: leptin adiponectin. The suggests midlife increased subsequent hormones long-term susceptibility On other hand, later life, decreases hormonal early manifestations precede onset promote pathology. Understanding contribution help identify pathological mechanisms AD, provide new putative targets for diagnosis therapy. This article part Special Issue entitled: Vascular Contributions Cognitive Impairment Dementia, edited by M. Paul Murphy, Roderick A. Corriveau Donna Wilcock.