Simulation of genomes: a review.

摘要: There is an increasing role of population genetics in human genetic research linking empirical observations with hypotheses about sequence variation due to historical and evolutionary causes. In addition, the data sets are size, genome-wide becoming a common place many studies. As far as more information available, it becomes clear that simplest not consistent data. Simulations will provide key tool contrast complex on real by generating simulated under hypothetical conditions we want contrast. Undoubtedly, developing tools for simulating large sequences at same time allow simulate natural selection, recombination demography patterns be great interest order better understanding trace left DNA different interacting forces. Simulation also essential evaluate sampling properties any statistics used association studies compare performance methods applied scales. Several recent simulation have been developed. Here, review some currently existing simulators which efficient scenarios. point out future directions this field already part current biology seems primary genome post-genomic biology.