Central leukotrienes modulate fever tolerance to LPS in rats.

摘要: Leukotrienes mediate several inflammatory events such as neutrophil chemoattraction, leukocyte adhesion, and central-release of cytokines fever. However, there is no information available about their putative role in lipopolysaccharide (LPS) tolerance. The rational the present study was to find out if central leukotrienes are involved development LPS Thus, we inhibited leukotriene synthesis tolerant rats using a pharmacological tool, i.e., selective inhibitor MK-886 injected into third ventricle (3V) rats. Body core temperature (Tb) measured datalogger placed inside abdominal cavity. A low-dose (100 μg/kg ip) given for 4 consecutive days induce At day 4, received microinjection 3V immediately before LPS, whereas control groups were treated with vehicle (saline). We observed that failed plasma surges, increased hypothalamic PGE2 levels fever 3 post treatment, aptly characterizing When saline, significant change Tb observed. full LPS-induced pretreated MK-886, which associated an enhancement levels, not accompanied by (IL-1β, IL-6) surges. These data consistent notion play tolerance LPS.