Effect of TPA and HTLV-1 Tax on BRCA1 and ERE controlled genes expression.
作者： Azhar Jabareen , Aya Abu-Jaafar , Ammar Abou-Kandil , Mahmoud Huleihel
DOI: 10.1080/15384101.2017.1327491
关键词: Activator (genetics) 、 Promoter 、 Suppressor 、 Biology 、 Classical complement pathway 、 Gene 、 Molecular biology 、 Cell biology 、 Receptor 、 Protein kinase C 、 Transcription factor
摘要: AbstractInterference with the expression and/or functions of multifunctional tumor suppressor BRCA1 leads to a high risk breast and ovarian cancers. is usually activated by estrogen (E2) liganded ERα receptor. Activated considered as potent transcription factor which activates various genes two pathways. A classical pathway, binds directly E2-responsive elements (EREs) in promoters responsive non-classical pathway where indirectly appropriate gene promoter. In our previous study, HTLV-1Tax was found strongly inhibit induced while stimulating ERE dependent genes. TPA strong PKC activator induce HTLV-1. Here we examined effect on controlled region MCF-7 cells Tax activity these Our results showed stimulatory both with...
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