Novel Anti-angiogenic Therapies Using Naturally Occurring and Synthetic Drugs to Combat Progestin-Dependent Breast Cancer

摘要: Angiogenesis, the process by which new blood vessels are formed, is essential for both normal and pathological tissue expansion provides nourishment necessary growth. The role of growth factors promote angiogenesis in pathologic conditions breast now well established. Recently synthetic progestin component combination estrogen hormone replacement therapy (HRT) has been associated with increased risk cancer postmenopausal women. We demonstrated that progestins induce cells to produce vascular endothelial factor (VEGF), a potent angiogenic promotes causes tumors grow. Unfortunately, antiprogestins toxic, precluding their use as means suppress proangiogenic activity administered progestins. In this chapter we will discuss our studies aimed at identifying naturally occurring compounds antiprogestin anti-angiogenic activities. describe progress using agents block production progestin-induced VEGF from also have capacity treat prevent progestin-dependent disease animal models. contend information gained such could facilitate development personalized medicine might be used more precisely selectively target specific signal transduction pathway angiogenesis, thereby controlling formation nourishing rapid hormone-dependent tumors. Our further concept “angio-prevention” individuals who particularly susceptible disease, example, women mutations tumor suppressors p53 Brca-1. By maintaining switch “off” within cells, cancers may prevented.