Antemortem Prediction of Braak Stage.

摘要: We examined the extent to which tauopathy distribution, as determined by Braak staging, might be predicted various risk factors in older individuals. The Swedish Twin Registry provided extensive information on neuropsychological function, lifestyle, and cardiovascular of 128 patients for whom autopsy data including staging were available. Logistic regression was used develop a prognostic model that targeted discrimination between stages 0 II III VI. analysis showed VI significantly having 1 or more APOE e4 alleles, age, high total cholesterol, absence diabetes disease, poorer scores Wechsler Adult Intelligence Score Information test, verbal fluency, recognition memory but better recall. algorithm well (receiver-operating characteristic area under curve, 0.897; 95% confidence interval, 0.842-0.951). Using cutoff 50% more, sensitivity 85%, specificity 70%, negative predictive value 69%. This study demonstrates distribution can accurately using combination antemortem patient data. These results provide further insight into development AD-related disease mechanisms suggest predicts spread neurofibrillary tangles above transentorhinal stage.