Fabrication of Polylactide-Based Biodegradable Thermoset Scaffolds for Tissue Engineering Applications

作者: Reika Sakai , Baiju John , Masami Okamoto , Jukka V. Seppälä , Jayasheelan Vaithilingam

DOI: 10.1002/MAME.201100436

关键词: Composite materialTissue engineeringPolymerizationThermal stabilityThermosetting polymerFabricationMaterials scienceNanotechnologyScaffoldBiocompatibilityBiodegradable polymerOrganic chemistryMaterials ChemistryGeneral Chemical EngineeringPolymers and Plastics

摘要: The fabrication of tissue engineering scaffolds based on the polymerization crosslinked polylactide using leaching and batch foaming to generate well-controlled interconnected biodegradable polymer is reported. scaffold parameters are studied in relation interpore connectivity, pore morphology, structural stability PLA scaffold. In vitro cell culture degradation used analyze biocompatibility biodegradability scaffolds. new thermoset highly suitable for bone applications due their complex internal architecture, thermal stability, biocompatibility.

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