Influence of ABCB1 gene polymorphisms on the pharmacokinetics of azithromycin among healthy Chinese Han ethnic subjects.
作者： Xiao-Jing He , Li-Mei Zhao , Feng Qiu , Ya-Xin Sun , Jesse Li-Ling
DOI: 10.1016/S1734-1140(09)70140-9
关键词: Chinese han 、 Regimen 、 Genotype 、 Pharmacology 、 Gastroenterology 、 Single oral dose 、 ABCB1 gene 、 Healthy volunteers 、 Medicine 、 Internal medicine 、 Azithromycin 、 Pharmacokinetics
摘要: Abstract The aim of this study was to evaluate the effects ABCB1 gene polymorphisms on azithromycin pharmacokinetics in Chinese Han ethnic subjects. In total, 20 healthy volunteers with various genotypes (6 2677GG/3435CC, 8 2677GT/3435CT, 6 2677TT/3435TT) were enrolled. Each given a single oral dose 500 mg azithromycin. Plasma concentration measured for up 96 h by LC/MS/MS. As shown, C max significantly lower among individuals 2677TT/3435TT genotype (468.0 ± 173.4 ng • h/ml) than those 2677GG/3435CC (911.2 ± 396.4 h/ml, p = 0.013). However, t value higher subjects (2.0 ± 0.5 h) 2677GT/3435CT (1.6 ± 0.3 h) or (1.4 ± 0.4 h) (p = 0.068 and p = 0.026, respectively). Furthermore, AUC last tended be (5000.2 ± 1610.0 vs . 4558.0 ± 805.0 4131.0 ± 995.1 ng/ml). Our results showed first time that may influenced particular gene. Individualized dosage regimen design incorporating such information improve efficacy drug while reducing adverse reactions.
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