Acryl Activation by Intramolecular Hydrogen Bond: Morita Baylis Hillman Reaction of Acrylamide with Broad Substrate Scope
关键词: Hydrogen bond 、 Intramolecular force 、 Baylis–Hillman reaction 、 Acrylamide 、 Alkene 、 DABCO 、 Michael reaction 、 Polymer chemistry 、 Chemistry
摘要: Use of acrylamide as an activated alkene in largely recognized Morita Baylis Hillman (MBH) reaction has been least explored owing to less reactivity Michael acceptor. Contrary have profound applications synthetic, medicinal and polymer chemistry. An intramolecular Hydrogen bond activated, MBH N-(2-hydroxyphenyl) developed. With various control experiments, role ortho hydroxy was found be activator critical for success reaction. Under the influence DABCO, designed acrylamides gave wide substrate scope including a number reactive aldehydes chemo selective reactions. Such mode activation can helpful design other reactions too. example presented by successful addition
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