The synthesis of pyrrolo[2,3-c][1,2,6]thiadiazine-5-carbonitriles from (4H-1,2,6-thiadiazin-4-ylidene)malononitriles
作者： Andreas S. Kalogirou , Panayiotis A. Koutentis , Maria D. Rikkou
DOI: 10.1016/J.TET.2010.01.044
关键词: Sodium methoxide 、 Chemistry 、 Malononitrile 、 Chemical synthesis 、 Nitrile 、 Organic chemistry 、 Reaction mechanism 、 Biochemistry 、 Drug discovery
摘要: Abstract [3,5-Bis(dialkylamino)-4H-1,2,6-thiadiazin-4-ylidene]propanedinitriles 6a–c, react with sodium methoxide or ethoxide to give the corresponding 6-alkoxy-4-dialkylamino substituted pyrrolo[2,3-c][1,2,6]thiadiazine-5-carbonitriles 7a–f in variable yields. These new compounds are fully characterised and two rational mechanisms proposed for their formation.
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