Cyclic AMP-responsive DNA-binding protein: structure based on a cloned placental cDNA
作者： J. Hoeffler , T. Meyer , Y Yun , J. Jameson , J. Habener
关键词: ATF/CREB 、 Peptide sequence 、 CREB 、 Biology 、 Transcription factor 、 Leucine zipper 、 CREB1 、 Biochemistry 、 Binding protein 、 Cyclic AMP Response Element-Binding Protein 、 Multidisciplinary
摘要: Cyclic AMP (cAMP) is an intracellular second messenger that activates transcription of many cellular genes. A palindromic consensus DNA sequence, TGACGTCA, functions as a cAMP-responsive transcriptional enhancer (CRE). The CRE binds protein 38 kD in placental JEG-3 cells. lambda gt11 library was screened for expression specific CRE-binding proteins with the sequence radioactive probe. cDNA encoding 326 amino acids binding properties (CREB) isolated. contains COOH-terminal basic region adjacent to similar "leucine zipper" believed be involved and protein-protein contacts several other DNA-associated including products c-myc, c-fos, c-jun oncogenes GCN4. CREB also NH2-terminal acidic proposed potential activation domain. putative DNA-binding domain structurally corresponding domains phorbol ester-responsive yeast factor
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