Disulfonimide-Catalyzed Asymmetric Reduction of N-Alkyl Imines.
作者： Vijay N. Wakchaure , Philip S. J. Kaib , Markus Leutzsch , Benjamin List
关键词: Alkyl 、 Hydrochloride 、 Brønsted–Lowry acid–base theory 、 Organic chemistry 、 Organocatalysis 、 Hydrogen 、 Chemistry 、 Catalysis
摘要: A chiral disulfonimide (DSI)-catalyzed asymmetric reduction of N-alkyl imines with Hantzsch esters as a hydrogen source in the presence Boc2 O has been developed. The reaction delivers Boc-protected amines excellent yields and enantioselectivity. method tolerates large variety alkyl amines, thus illustrating potential for general reductive cross-coupling ketones diverse it was applied synthesis pharmaceuticals (S)-Rivastigmine, NPS R-568 Hydrochloride, (R)-Fendiline.
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