Potential Involvement of BIRC5 in Maintaining Pluripotency and Cell Differentiation of Human Stem Cells.

摘要: The BIRC5 gene encodes a survivin protein belonging to class III of inhibitors apoptosis, IAP. This serves dual role. First, it regulates cell death, and second, is an important regulator mitosis progression, although its physiological regulatory function has not been fully understood. Many studies have shown confirmed that practically absent in mature tissues nature, while overexpression reported many cancerous tissues. There little information about the significance expression normal adult human stem cells. paper presents study analysis at transcription level using qPCR method, hematopoietic cells from peripheral blood mobilized with granulocyte growth factor, adherent derived umbilical cord, bone marrow this was also examined healthy individuals. results more are, lower is. lowest found cells, highest CD34+ CD105 tested material higher Stem culture show expression. confirms involvement IAP family processes apart apoptosis inhibition. possible effect on proliferation; cycle, differentiation, survival, maintenance cells; antineoplastic properties mesenchymal demonstrated. Our research suggests may be responsible for condition pluripotency high dedifferentiation tumor