Targeting the Dimerization of the Main Protease of Coronaviruses: A Potential Broad-Spectrum Therapeutic Strategy.

摘要: A new coronavirus (CoV) caused a pandemic named COVID-19, which has become global health care emergency in the present time. The virus is referred to as SARS-CoV-2 (severe acute respiratory syndrome-coronavirus-2) and genome similar (∼82%) that of previously known SARS-CoV (SARS coronavirus). An attractive therapeutic target for CoVs main protease (Mpro) or 3-chymotrypsin-like cysteine (3CLpro), this enzyme plays key role polyprotein processing active dimeric form. Further, Mpro highly conserved among various CoVs, mutation often lethal virus. Thus, drugs targeting significantly reduce risk mutation-mediated drug resistance display broad-spectrum antiviral activity. combinatorial design peptide-based inhibitors dimerization represents potential strategy. In regard, we have compiled literature reports highlighting effect mutations N-terminal deletion residues on its and, thus, catalytic We believe review will stimulate research less explored yet quite significant area. COVID-19 epidemic possibility future CoV outbreaks strongly emphasize urgent need development potent agents against infections.