Enhanced biocompatibility of PAMAM dendrimers benefiting from tuning their surface charges.

作者: Yanshuai Cui , Bo Liang , Longgang Wang , Linlin Zhu , Jianxin Kang

DOI: 10.1016/J.MSEC.2018.07.070

关键词: DendrimerNanomedicineCysteamineMaterials scienceBiophysicsConjugated systemCytotoxicityBiocompatibilityMaleic anhydrideSurface charge

摘要: … The surface charge of dendrimers is one of the key factors that determine their use in nanomedicine. Generation 5 poly(amido amine) dendrimers (G5 PAMAM) encapsulating with …

参考文章(45)
Chuan Leng, Hsiang-Chieh Hung, Shuwen Sun, Dayang Wang, Yuting Li, Shaoyi Jiang, Zhan Chen, Probing the Surface Hydration of Nonfouling Zwitterionic and PEG Materials in Contact with Proteins. ACS Applied Materials & Interfaces. ,vol. 7, pp. 16881- 16888 ,(2015) , 10.1021/ACSAMI.5B05627
N Malik, R Wiwattanapatapee, R Klopsch, K Lorenz, H Frey, J.W Weener, E.W Meijer, W Paulus, R Duncan, Dendrimers: relationship between structure and biocompatibility in vitro, and preliminary studies on the biodistribution of 125I-labelled polyamidoamine dendrimers in vivo. Journal of Controlled Release. ,vol. 65, pp. 133- 148 ,(2000) , 10.1016/S0168-3659(99)00246-1
Wolfgang G. Kreyling, Abuelmagd M. Abdelmonem, Zulqurnain Ali, Frauke Alves, Marianne Geiser, Nadine Haberl, Raimo Hartmann, Stephanie Hirn, Dorleta Jimenez de Aberasturi, Karsten Kantner, Gülnaz Khadem-Saba, Jose-Maria Montenegro, Joanna Rejman, Teofilo Rojo, Idoia Ruiz de Larramendi, Roser Ufartes, Alexander Wenk, Wolfgang J. Parak, In vivo integrity of polymer-coated gold nanoparticles Nature Nanotechnology. ,vol. 10, pp. 619- 623 ,(2015) , 10.1038/NNANO.2015.111
Lan Jia, Jian-Ping Xu, Hai Wang, Jian Ji, Polyamidoamine dendrimers surface-engineered with biomimetic phosphorylcholine as potential drug delivery carriers. Colloids and Surfaces B: Biointerfaces. ,vol. 84, pp. 49- 54 ,(2011) , 10.1016/J.COLSURFB.2010.12.012
R DUNCAN, L IZZO, Dendrimer biocompatibility and toxicity. Advanced Drug Delivery Reviews. ,vol. 57, pp. 2215- 2237 ,(2005) , 10.1016/J.ADDR.2005.09.019
Stefan Tenzer, Dominic Docter, Jörg Kuharev, Anna Musyanovych, Verena Fetz, Rouven Hecht, Florian Schlenk, Dagmar Fischer, Klytaimnistra Kiouptsi, Christoph Reinhardt, Katharina Landfester, Hansjörg Schild, Michael Maskos, Shirley K. Knauer, Roland H. Stauber, Rapid formation of plasma protein corona critically affects nanoparticle pathophysiology Nature Nanotechnology. ,vol. 8, pp. 772- 781 ,(2013) , 10.1038/NNANO.2013.181
Xiaole Qi, Yuchao Fan, Huan He, Zhenghong Wu, Hyaluronic acid-grafted polyamidoamine dendrimers enable long circulation and active tumor targeting simultaneously. Carbohydrate Polymers. ,vol. 126, pp. 231- 239 ,(2015) , 10.1016/J.CARBPOL.2015.03.019
István J. Majoros, Balázs Keszler, Scott Woehler, Tricia Bull, James R. Baker, Acetylation of Poly(amidoamine) Dendrimers Macromolecules. ,vol. 36, pp. 5526- 5529 ,(2003) , 10.1021/MA021540E
Wei Wu, Wouter Driessen, Xiqun Jiang, Oligo(ethylene glycol)-Based Thermosensitive Dendrimers and Their Tumor Accumulation and Penetration Journal of the American Chemical Society. ,vol. 136, pp. 3145- 3155 ,(2014) , 10.1021/JA411457R
Zheng Qiao, Xiangyang Shi, Dendrimer-based molecular imaging contrast agents Progress in Polymer Science. ,vol. 44, pp. 1- 27 ,(2015) , 10.1016/J.PROGPOLYMSCI.2014.08.002