The role of genes and environment in the etiology of PCOS

摘要: Both genes and the environment contribute to PCOS. Obesity, exacerbated by poor dietary choices physical inactivity, worsens PCOS in susceptible individuals. The role of other environmental modifiers such as infectious agents or toxins are speculative. Phenotype confusion has characterized genetic studies Although several loci have been proposed including CYP11A, insulin gene, follistatin a region near receptor, evidence supporting linkage is not overwhelming. strongest case can be made for recept gene (but involving this gene), it identified two separate studies, perhaps most importantly yet refuted larger studies. However, responsible at chromosome 19p13.3 remains identified. To date, no that causes contributes substantially development phenotype.