Antenatal corticosteroids and cranial ultrasonographic abnormalities
作者： Alan Leviton , Olaf Dammann , Elizabeth N Allred , Karl Kuban , Marcello Pagano
DOI: 10.1016/S0002-9378(99)70344-3
关键词: Central nervous system disease 、 Vascular disease 、 Umbilical cord 、 Cerebral palsy 、 Retrospective cohort study 、 Intraventricular hemorrhage 、 Medicine 、 Vasculitis 、 Obstetrics 、 Surgery 、 Ventriculomegaly 、 Obstetrics and gynaecology
摘要: Abstract Objective: This study was undertaken to determine whether very-low-birth-weight infants whose mothers received a course of antenatal corticosteroids were at decreased risk for 3 cranial ultrasonographic entities that predict neurodevelopmental dysfunction. Study Design: retrospective cohort evaluated 1604 weighing 500 1500 g who underwent ≥1 scans required by design specified postnatal intervals and own mother's hospital charts reviewed. Infants classified according (none, partial, or complete). Results: In the total sample risks intraventricular hemorrhage an echolucent image in cerebral white matter only modestly (and not statistically significantly) reduced after full corticosteroids, whereas appeared significantly reduce ventriculomegaly even partial course. Antenatal halve among gestationally youngest those with hemorrhage, hypothyroxinemia, vasculitis umbilical cord chorionic plate placenta. Conclusion: These observations are consistent hypothesis protect infants, especially most vulnerable, against abnormalities. (Am J Obstet Gynecol 1999;181:1007-17.)
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