Brain death increases COX-1 and COX-2 expression in the renal medulla in a pig model.

摘要: Background Brain death is linked to a systemic inflammatory response that includes prostaglandins and cytokines among its mediators. The levels of cyclooxygenase-1 cyclooxygenase-2 (COX-1 COX-2) affect graft survival, but it remains unknown whether these enzymes are modified during brain death. aims this study were investigate the organ expression COX analyse cytokine in plasma, cerebrospinal fluid (CSF), organs porcine model intracerebral haemorrhage death. Methods Twenty pigs randomly assigned either group or control group. Brain was induced by an injection blood, animals observed over next 8 h. Tissue samples tested for COX-1, COX-2 messenger RNA (mRNA) (heart, lung, kidney), haeme oxygenase-1 (HO-1) (kidney), interleukin-1β (IL-1β), IL-6, IL-8, IL-10, tumour necrosis factor-α. These also measured at eight time points plasma CSF. Results At level, COX-1 mRNA increased only renal medulla (P = 0.03 P = 0.02, respectively). tissue, CSF revealed no differences between groups. HO-1 decreased (P = 0.0088). Conclusion Brain increases medulla. release into did not vary