ID1 overexpression increases gefitinib sensitivity in non-small cell lung cancer by activating RIP3/MLKL-dependent necroptosis.

作者: Hor-Yue Tan , Ning Wang , Yau-Tuen Chan , Cheng Zhang , Wei Guo

DOI: 10.1016/J.CANLET.2020.01.025

关键词: Protein kinase BProtein kinase ACancer researchTyrosine-kinase inhibitorProgrammed cell deathLung cancerGefitinibNecroptosisMedicineCancer

摘要: … lung cancer tissue (Fig. 5E). To further confirm the role of RIP3 and MLKL in ID1 overexpression-mediated NSCLC sensitivity to gefitinib, we performed specific knockdown of RIP3 …

参考文章(47)
Tae-In Park, Yu-Mi Lee, Sunzoo Kim, Young-Min Jo, Mee-Seon Kim, Expression of Id-1 and VEGF in non-small cell lung cancer. International Journal of Clinical and Experimental Pathology. ,vol. 6, pp. 2102- 2111 ,(2013)
Danqing Chen, Shiva S. Forootan, John R. Gosney, Farzad S. Forootan, Youqiang Ke, Increased expression of Id1 and Id3 promotes tumorigenicity by enhancing angiogenesis and suppressing apoptosis in small cell lung cancer Genes & Cancer. ,vol. 5, pp. 212- 225 ,(2014) , 10.18632/GENESANDCANCER.20
Lihua Huang, Liwu Fu, Mechanisms of resistance to EGFR tyrosine kinase inhibitors Acta Pharmaceutica Sinica B. ,vol. 5, pp. 390- 401 ,(2015) , 10.1016/J.APSB.2015.07.001
Jianguo Xia, Erin E Gill, Robert E W Hancock, NetworkAnalyst for statistical, visual and network-based meta-analysis of gene expression data Nature Protocols. ,vol. 10, pp. 823- 844 ,(2015) , 10.1038/NPROT.2015.052
Takahiro Nakajima, Takashi Anayama, Yasushi Matsuda, David M. Hwang, Patrick Z. McVeigh, Brian C. Wilson, Gang Zheng, Shaf Keshavjee, Kazuhiro Yasufuku, Orthotopic Lung Cancer Murine Model by Nonoperative Transbronchial Approach The Annals of Thoracic Surgery. ,vol. 97, pp. 1771- 1775 ,(2014) , 10.1016/J.ATHORACSUR.2014.01.048
F. Cappuzzo, E. Magrini, G. L. Ceresoli, S. Bartolini, E. Rossi, V. Ludovini, V. Gregorc, C. Ligorio, A. Cancellieri, S. Damiani, A. Spreafico, C. T. Paties, L. Lombardo, C. Calandri, G. Bellezza, M. Tonato, L. Crino, Akt phosphorylation and gefitinib efficacy in patients with advanced non-small-cell lung cancer. Journal of the National Cancer Institute. ,vol. 96, pp. 1133- 1141 ,(2004) , 10.1093/JNCI/DJH217
Esther HA Sim, Ian A Yang, Richard Wood-Baker, Rayleen V Bowman, Kwun M Fong, Gefitinib for advanced non-small cell lung cancer. Cochrane Database of Systematic Reviews. ,vol. 2018, pp. 0- 0 ,(2007) , 10.1002/14651858.CD006847.PUB2
Seon Young Nam, Gyung-Ah Jung, Gwong-Cheung Hur, Hee-Yong Chung, Woo Ho Kim, Dai-Wu Seol, Byung Lan Lee, Upregulation of FLIPS by Akt, a possible inhibition mechanism of TRAIL-induced apoptosis in human gastric cancers Cancer Science. ,vol. 94, pp. 1066- 1073 ,(2003) , 10.1111/J.1349-7006.2003.TB01402.X
Eduardo Castañon, Joaquim Bosch-Barrera, Inés López, Víctor Collado, Marta Moreno, José María López-Picazo, Leire Arbea, María Dolores Lozano, Alfonso Calvo, Ignacio Gil-Bazo, Id1 and Id3 co-expression correlates with clinical outcome in stage III-N2 non-small cell lung cancer patients treated with definitive chemoradiotherapy Journal of Translational Medicine. ,vol. 11, pp. 13- 13 ,(2013) , 10.1186/1479-5876-11-13
X Zhang, M-T Ling, H Feng, Y C Wong, S W Tsao, X Wang, Id-1 stimulates cell proliferation through activation of EGFR in ovarian cancer cells British Journal of Cancer. ,vol. 91, pp. 2042- 2047 ,(2004) , 10.1038/SJ.BJC.6602254