Theiler’s Murine Encephalomyelitis Virus (TMEV) Infection in Mice as a Model for Multiple Sclerosis

摘要: Theiler’s murine encephalomyelitis viruses (TMEV) are enteric pathogens of mice and members the Picornaviridae family. The nucleotide sequence TMEV predicted amino acid sequences TMEV-encoded proteins have been compared with other picornaviruses, a close relationship exists encephalomyocarditis virus (EMCV), indicating that belong to cardiovirus subgroup picornaviruses. However, type neurologic involvement produce is quite distinct from cardioviruses. Following intracerebral (IC) inoculation, certain strains unique biphasic central nervous system (CNS) disease in their natural host [1,2], characterized by poliomyelitis during first month post infection, chronic, inflammatory demyelinating disorder weeks months later surviving animals. Mice infected tissue culture-adapted do not develop clinical polio but after prolonged (30–60 days) incubation period [3]. demyelination related persistent infection wherein for many low levels infectious can be recovered target organ, CNS [1,4].