Insights into rheumatoid arthritis derived from the Sa immune system.

摘要: The Sa system is a recently described immune that has specificity and positive predictive value of nearly 100% for rheumatoid arthritis (RA) in Asia, Europe the Americas. Its sensitivity 30-40% suggests it identifies subset RA patients. Anti-Sa antibodies are present from disease onset severity. reactants plentiful target tissue: antigen synovium, IgG antibody fluid. Immunologically, hapten-carrier which vimentin carrier citrulline hapten. citrullination closely related to apoptosis, citrullinated extremely sensitive digestion by ubiquitous calpains. Nevertheless, found only few cell lines. Calpastatin, natural specific inhibitor calpains, also RA-associated, albeit non-specific, autoimmune system. Is possible calpain-related apoptotic pathways could be prominent cells containing Sa? task reconcile Sa/citrullinated proteins multifactorial polygenic such as RA.