Bone loss after renal transplantation: role of hyperparathyroidism, acidosis, cyclosporine and systemic disease.
作者： James Heaf , Erling Tvedegaard , Inge-Lis Kanstrup , Niels Fogh-Andersen
DOI: 10.1034/J.1399-0012.2000.140503.X
关键词: Renal function 、 Urology 、 Endocrinology 、 Bone density 、 Internal medicine 、 Tertiary hyperparathyroidism 、 Transplantation 、 Kidney 、 Bone disease 、 Medicine 、 Bone mineral 、 Hyperparathyroidism
摘要: UNLABELLED In order to determine risk factors for bone loss after renal transplantation, dual energy X-ray absorptiometry was performed in 125 transplant patients. The mineral density (BMD) expressed as a percentage of the normal population (BMD%) and Z-score (SD from normal). whole body, lumbar spine femoral neck BMD% (Z-score) values were 93.9 +/- 8.9 (-0.90 SD), 91.6 14.9 (-0.98 SD) 87 15.3 (-1.0 SD)%, respectively. Low associated with low creatinine clearance ( 40 mL/min: 95.6 8.0, p 1: 87.4 9.3, 5: 90.1 10.6, 27: 96.7 7.2, 200: 87.7 5.0, 300: 85.6 13.2, 100: 89.3 7.6, 10: 82.1 20.1, 20: 96.9 7.4, 150: 92.1 550: 94.2 7.8, 3 microg/wk: 97.3 6.9, < 0.05). No relationships transplantation duration, 1,25-OH-vitamin D, aluminium, calcium or steroid dose found. involutional changes tertiary hyperparathyroidism could be discerned. CONCLUSION major threats mass appear ongoing hyperparathyroid disease, function, acidosis, systemic disease hypo-vitaminosis D.
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