Are predictions of cancer response to targeted drugs, based on effects in unrelated tissues, the ‘Black Swan’ events?

摘要: Adverse effects of targeted drugs on normal tissues can predict the cancer response. Rash correlates with efficacy erlotinib, cetuximab and gefitinib onset arterial hypertension response to bevacizumab, sunitinib, axitinib sorafenib, possible examples ‘Black Swan’ events, unexpected scientific observations, as described by Karl Popper in 1935. The proposition is that our patients have individual intrinsic variants cell growth control, important for tumor adverse tumor-unrelated tissue. This means lack predictive side healthy tissue linked poor results therapy when resistance caused mechanisms protect all cells patient from drug effects.