Fabrication of Porous Poly(ε-caprolactone) Scaffolds Containing Chitosan Nanofibers by Combining Extrusion Foaming, Leaching, and Freeze-Drying Methods
作者： Xin Jing , Hao-Yang Mi , Travis Cordie , Max Salick , Xiang-Fang Peng
DOI: 10.1021/IE5034073
关键词: Biocompatibility 、 Chitosan 、 Porosity 、 Extrusion 、 Leaching (metallurgy) 、 Nanofiber 、 Polymer chemistry 、 Materials science 、 Chemical engineering 、 Caprolactone 、 Ethylene oxide
摘要: Biomimetic porous poly(e-caprolactone) (PCL) scaffolds containing chitosan nanofibers (CSNF) were produced by using a hybrid process that combines extrusion foaming, water-soluble phase leaching, and freeze-drying. The high porosity interconnectivity of the achieved supercritical fluid foaming addition poly(ethylene oxide) (PEO) sodium chloride (NaCl) as porogens. after leaching was over 78%. structure introduced into micropores similar to collagen bundles in extracellular matrix (ECM). enhanced compressive modulus slightly improved water uptake ability much 35% compared without chitosan. A 3T3 fibroblast cell culture performed investigate biocompatibility scaffolds, which revealed cells proliferated better on PCL/chitosan than PCL scaffo...
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