The natural compound forskolin synergizes with dexamethasone to induce cell death in myeloma cells via BIM
作者： Virginie Follin-Arbelet , Kristine Misund , Elin Hallan Naderi , Hege Ugland , Anders Sundan
DOI: 10.1038/SREP13001
关键词: Apoptosis 、 Forskolin 、 Colforsin 、 Pharmacology 、 Doxorubicin 、 Cyclic adenosine monophosphate 、 Cell culture 、 Dexamethasone 、 Biology 、 Bortezomib
摘要: We have previously demonstrated that activation of the cyclic adenosine monophosphate (cAMP) pathway kills multiple myeloma (MM) cells both in vitro and vivo. In present study we investigated potential enhancing killing MM cell lines primary by combining cAMP-elevating compound forskolin with commonly used therapeutic drugs melphalan, cyclophosphamide, doxorubicin, bortezomib dexamethasone. observed potentiated induced all tested agents as compared to treatment single alone. particular, had a synergistic effect on dexamethasone-responsive H929 OM-2. By knocking down proapoptotic BCL-2 family member BIM, proved this protein be involved induction apoptosis dexamethasone forskolin. The ability maintain even at lower concentrations conventional suggests may diminish treatment-associated side effects. Our findings support role combination current MM.
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