[36] Murine lupus
作者： Syamal K. Datta
DOI: 10.1016/0076-6879(88)62094-5
关键词: Lupus nephritis 、 Immunology 、 Biology 、 Mouse strain 、 Glomerulonephritis 、 Gene 、 Murine lupus 、 Antibody 、 Strain (chemistry)
摘要: Abstract In mice with lupus nephritis qualitative changes in anti-DNA antibodies occur, such as IgG switch and increased cationic charge, to render these pathogenic. Pathogenic idiotypes can be encoded by genes of a normal mouse strain SWR, where they remain dormant. When the are crossed an autoimmune like NZB, F1 hybrids express owing defects immunoregulation, resulting development lethal glomerulonephritis.
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