Soluble ST2 as a prognostic marker in community-acquired pneumonia
作者： Masato Watanabe , Hajime Takizawa , Masaki Tamura , Akira Nakajima , Daisuke Kurai
DOI: 10.1016/J.JINF.2015.02.004
关键词: C-reactive protein 、 Immunology 、 Internal medicine 、 Area under the curve 、 Univariate analysis 、 Hazard ratio 、 Community-acquired pneumonia 、 Pneumonia severity index 、 Medicine 、 Biomarker (medicine) 、 Pneumonia 、 Gastroenterology
摘要: Summary Objectives Community-acquired pneumonia (CAP) is associated with high mortality when initial treatment fails. Early identification of these patients allows physicians to modify treatments earlier, increasing survival. Methods Ninety-one hospitalized CAP were studied. Serum soluble ST2 levels measured at diagnosis and 3, 7, 14 days (days 0, 14) after the initiation antimicrobial treatment. The predictive value all-cause in-hospital additive effect on severity index (PSI) evaluated. Results In univariate analysis, serum death (hazard ratios: 3.1, 10.0, 12.0, 22.6, respectively). multivariate a combination day 3 (above 2700 pg/ml) PSI higher accuracy than alone (net reclassification improvement, 0.44; integrated discrimination 0.17; P = 0.001 for both). Specifically, simultaneous presence (day 3) 5 was suggestive risk (mortality 78% vs. 39%, Conclusions Soluble prognostic indicator can add of the PSI.
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