Epidemiology of severe sepsis occurring in the first 24 hrs in intensive care units in England, Wales, and Northern Ireland

摘要: OBJECTIVE: To investigate the numbers, clinical characteristics, resource use, and outcomes of admissions who met precise physiologic criteria for severe sepsis (as defined in PROWESS trial) first 24 hrs intensive care unit. DESIGN: Observational cohort study, with retrospective analysis prospectively collected data. SETTING: Ninety-one adult general units England, Wales, Northern Ireland between 1995 2000. PATIENTS: Patients were 56,673 admissions. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: We found that 27.1% unit Most nonsurgical (67%), most common organ system dysfunctions seen cardiovascular (88%) respiratory (81%) systems. Modeling data England Wales 1997 suggested 51 (95% confidence interval, 46-58) per 100,000 population year admitted to hrs.Of hrs, 35% died before discharge 47% during their hospital stay. Hospital mortality rate ranged from 17% 16-19 age group 64% those >85 yrs. In 1997, an estimated 21-28) after hrs. For median length stay was 3.56 days (interquartile range, 1.50-9.32) 18 8-36 days). These used 45% 33% bed by all CONCLUSIONS: Severe is presents a major challenge clinicians, managers, healthcare policymakers. Intensive meeting have high use.