Association of LEP G2548A and LEPR Q223R Polymorphisms with Cancer Susceptibility: Evidence from a Meta-Analysis

摘要: markdownabstract__Background:__ Numerous epidemiological studies have examined associations of genetic variations in LEP (G2548A, -2548 nucleotide upstream the ATG start site) and LEPR (Q223R, nonsynonymous SNP exon 6) with cancer susceptibility; however, findings are inconsistent. Therefore, we performed a meta-analysis to comprehensively evaluate such associations. __Methods:__ We searched published literature from MEDLINE, EMBASE, Web Science CBM for eligible publications. also assessed genotype-based mRNA expression data HapMap rs7799039 (G2548A) rs1137101 (Q223R) normal cell lines derived 270 subjects different ethnicities. __Results:__ The final analysis included 16 6569 cases 8405 controls G2548A 19 7504 9581 Q223R. Overall, was statistically significantly associated an increased risk overall (AA vs. GG: OR=1.27, 95% CI=1.05-1.54; recessive model: OR=1.19, CI=1.00-1.41). Further stratifications by type showed prostate (recessive OR=1.26, CI=1.05-1.51) but not other cancers. For Q223R, no statistical evidence association found all; further stratification ethnicity Africans No differences were among genotypes or ethnicity. __Conclusions:__ Despite some limitations, this between 2548AA genotype cancer, particularly given variant did effect on expression, warrants additional validation large well-designed studies.