Respiratory herpes simplex virus type 1 infection/colonisation in the critically ill: marker or mediator?

摘要: Background: The clinical significance and pulmonary pathogenicity of herpes simplex virus type 1 (HSV-1) in mechanically ventilated, critically ill patients are unclear. Objective: To determine the features course respiratory HSV-1 infections/colonisations ill, order to evaluate contribution outcome. Design: A retrospective cohort study intensive care unit an university hospital, involving 22 with a isolated from bronchoalveolar lavage (BAL) fluid, divided into survivors (n=13) non-survivors (n=9). All except for one survivor had been intubated were ventilated. Results: Non-survivors acquired sooner on mechanical ventilation than survivors. Prior chronic heart disease was more prevalent and, at time isolation, mean creatinine level higher (P<0.05) former. Survivors somewhat greater fall body temperature after 10-day antiviral therapy non-survivors, but lung radiographic abnormalities prior did not differ. There no major differences cardiorespiratory variables between outcome groups causes death judged relate, general, HSV-1. Conclusions: Critically whom BAL is isolated, have about 40% chance dying, mainly because severe underlying comorbidity, which may predispose endogenous reactivation virus. evidence direct beneficial effects therapy. secretions thus be marker rather mediator illness.