Fetal grafting for Parkinson's disease: Expression of immune markers in two patients with functional fetal nigral implants

摘要: In a number of centers throughout the world, fetal nigral transplantation is being performed for treatment Parkinson's disease (PD). Clinical results have been inconsistent. One parameter that differs among transplant studies degree and manner by which patients are immunosuppressed following transplantation. Indeed, role immune system grafting in humans not well understood. Recently, two from our open label trial received implants come to autopsy. These were with cyclosporin 6 mo posttransplantation survived total 18 postgrafting. Robust survival grafted dopamine-containing cells was observed both cases. Immunostaining HLA-DR revealed dense collection within grafts staining rarely host including nongrafted regions striatum. A more detailed analysis markers Case 2. Numerous pan macrophages, T-cells, B-cells graft sites located postcommissural putamen. contrast, these ungrafted anterior findings suggest even healthy appearing functional implants, invaded could compromise their long-term viability function. Alternatively, known secrete trophic factors, may ultimately favor Further work needed understand grafting.