Non-axial administration of fentanyl in childbirth: a review of the efficacy and safety of fentanyl for mother and neonate

摘要: Abstract Objective to investigate the use of fentanyl for pain relief during childbirth administered by routes other than epidural or spinal (non-axial). In particular, aspects relating efficacy and safety mother neonate are explored. Background currently, pethidine is most widely used intramuscular opioid labour but has been shown have numerous side-effects on neonate. An alternative opioid, fentanyl, fewer both pethidine. Therefore, its was examined in this literature review. Review methods a search articles administration via non-axial conducted using electronic databases, key journals reference lists selected research papers reviews. Results only studies IV were identified from findings showed that appeared be safe, efficacious when childbirth. Fentanyl short-acting analgesic causing less sedation nausea adults addition, no long-term fetal neonatal effects identified, with normal neurological adaptive capacities at two hours 24 after birth supporting safe Key conclusion found efficacious, providing prompt analgesia minimal infant intravenously (IV) found. Recommendations further there paucity maternal, IV. Further should explore alternate such as subcutaneous, sublingual nasal which invasive can midwives. Implication practice confirming childbirth, benefits include midwives being able offer women an option relief. Alternative routes, managed through standing order, potentially reducing need additional resources. will benefit midwifery rural remote settings where resources access specialised services limited.