Pilot study of high-intensity focused ultrasound ablation as a bridging therapy for hepatocellular carcinoma patients wait-listed for liver transplantation.
作者： Kenneth SH Chok , Tan To Cheung , Regina CL Lo , Ferdinand SK Chu , Simon HY Tsang
DOI: 10.1002/LT.23892
关键词: Randomized controlled trial 、 Ablation 、 Ascites 、 Liver transplantation 、 High-intensity focused ultrasound 、 Liver disease 、 Surgery 、 Medicine 、 Liver function 、 Hepatocellular carcinoma 、 Urology
摘要: The objective of this study was to investigate the outcomes high-intensity focused ultrasound (HIFU) ablation as a bridging therapy for patients with hepatocellular carcinoma (HCC) who had been wait-listed deceased donor liver transplantation (DDLT). Adult unresectable and unablatable HCCs within University California San Francisco criteria DDLT were screened their suitability HIFU if they not suitable transarterial chemoembolization (TACE). Treatment receiving ablation, TACE, best medical treatment (BMT) compared. Fifty-one included in analysis. Before introduction only 39.2% received (TACE only, n = 20). With use, rate increased dramatically 80.4% (TACE + HIFU, n = 41). overall dropout 51% (n = 26). Patients BMT group significantly higher (P = 0.03) poorer function reflected by Model End-Stage Liver Disease scores Child-Pugh grading. Clinically relevant ascites found 5 2 group, but none TACE (P = 0.01 P = 0.03, respectively). groups comparable percentages tumor necrosis excised livers (P = 0.35), both than that P = 0.02, In conclusion, safe even HCC C disease. Its adoption percentage from 80.4%. A randomized controlled trial further validation its efficacy is warranted. Transpl 20:912–921, 2014. © 2014 AASLD.
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James E. Kennedy, High-intensity focused ultrasound in the treatment of solid tumours. Nature Reviews Cancer. ,vol. 5, pp. 321- 327 ,(2005) , 10.1038/NRC1591
Josep M Llovet, Jordi Bruix, Systematic review of randomized trials for unresectable hepatocellular carcinoma: Chemoembolization improves survival Hepatology. ,vol. 37, pp. 429- 442 ,(2003) , 10.1053/JHEP.2003.50047
Matteo Cescon, Alessandro Cucchetti, Matteo Ravaioli, Antonio Daniele Pinna, Hepatocellular carcinoma locoregional therapies for patients in the waiting list. Impact on transplantability and recurrence rate. Journal of Hepatology. ,vol. 58, pp. 609- 618 ,(2013) , 10.1016/J.JHEP.2012.09.021
Geert Maleux, Hannah van Malenstein, Vincent Vandecaveye, Sam Heye, Johan Vaninbroukx, Frederik Nevens, Chris Verslype, Transcatheter Chemoembolization of Unresectable Hepatocellular Carcinoma: Current Knowledge and Future Directions Digestive Diseases. ,vol. 27, pp. 157- 163 ,(2009) , 10.1159/000218348
Paige M. Porrett, Heather Peterman, Mark Rosen, Seema Sonnad, Michael Soulen, James F. Markmann, Abraham Shaked, Emma Furth, K. Rajender Reddy, Kim Olthoff, Lack of benefit of pre‐transplant locoregional hepatic therapy for hepatocellular cancer in the current MELD era Liver Transplantation. ,vol. 12, pp. 665- 673 ,(2006) , 10.1002/LT.20636
Tan To Cheung, Kenneth SH Chok, Regina CL Lo, William W Sharr, See Ching Chan, Ronnie TP Poon, Sheung Tat Fan, Chung Mau Lo, High-intensity focused ultrasound ablation as a bridging therapy for hepatocellular carcinoma patients awaiting liver transplantation Hepatobiliary & Pancreatic Diseases International. ,vol. 11, pp. 542- 544 ,(2012) , 10.1016/S1499-3872(12)60221-5
Jordi Bruix, Morris Sherman, Josep M Llovet, Michel Beaugrand, Riccardo Lencioni, Andrew K Burroughs, Erik Christensen, Luigi Pagliaro, Massimo Colombo, Juan Rodés, None, Clinical Management of Hepatocellular Carcinoma. Conclusions of the Barcelona-2000 EASL Conference Journal of Hepatology. ,vol. 35, pp. 421- 430 ,(2001) , 10.1016/S0168-8278(01)00130-1
Francis Y Yao, Linda Ferrell, Nathan M Bass, Jessica J Watson, Peter Bacchetti, Alan Venook, Nancy L Ascher, John P Roberts, Liver transplantation for hepatocellular carcinoma: Expansion of the tumor size limits does not adversely impact survival Hepatology. ,vol. 33, pp. 1394- 1403 ,(2001) , 10.1053/JHEP.2001.24563
Kelvin KC Ng, Ronnie TP Poon, See Ching Chan, Kenneth SH Chok, Tan To Cheung, Helen Tung, Ferdinand Chu, Wai Kuen Tso, Wan Ching Yu, Chung Mau Lo, Sheung Tat Fan, None, High-Intensity Focused Ultrasound for Hepatocellular Carcinoma A Single-Center Experience Annals of Surgery. ,vol. 253, pp. 981- 987 ,(2011) , 10.1097/SLA.0B013E3182128A8B
Shawn J. Pelletier, Sherry Fu, Veena Thyagarajan, Carlos Romero-Marrero, Mashal J. Batheja, Jeffrey D. Punch, John C. Magee, Anna S. Lok, Robert J. Fontana, Jorge A. Marrero, An intention-to-treat analysis of liver transplantation for hepatocellular carcinoma using organ procurement transplant network data Liver Transplantation. ,vol. 15, pp. 859- 868 ,(2009) , 10.1002/LT.21778