Enlarged ventricles, astrogliosis and neurodegeneration in heat shock factor 1 null mouse brain
作者： S.D Santos , M.J Saraiva
DOI: 10.1016/J.NEUROSCIENCE.2004.03.023
关键词: Neuroscience 、 Genetically modified mouse 、 HSF1 、 Neurodegeneration 、 Heat shock protein 、 Hsp27 、 Astrogliosis 、 Lateral ventricles 、 Cell biology 、 Heat shock factor 、 Biology
摘要: Abstract Heat shock transcription factors mediate the regulation of organism physiological maintenance and adaptation. We investigated morphology cellular expression selected genes in brains transgenic mice lacking heat factor 1, HSF1, main transactivator under stress conditions. All HSF1 null displayed major brain morphological alterations: lateral ventricles were markedly enlarged white matter reduced, as ventriculomegaly. Heterozygous for gene also had these abnormalities albeit to a lower extent comparison wild type, indicating dosage effect. Cell loss, vacuolisation, amorphous eosinophilic cytoplasm pyknotic nucleus evident matter, especially periventricular regions. These areas exhibited astrogliosis neurodegeneration. The protein hsp 27 was up-regulated whereas α B-crystallin down-regulated different mouse control mice. data implicate maintaining postnatal mammalian non-stress
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