Prevention of fatal postoperative pulmonary embolism by low-dose heparin.
作者： UlrichF. Gruber , François Duckert , Raimund Fridrich , Josef Rem , Joachim Torhorst
DOI: 10.1016/S0140-6736(77)91213-2
关键词: Pulmonary embolism 、 Prospective cohort study 、 Population 、 Incidence (epidemiology) 、 Clinical research 、 Surgery 、 Thrombosis 、 Embolism 、 Heparin 、 Medicine
摘要: The efficacy of low-dose heparin to prevent fatal postoperative pulmonary embolism was investigated in this multicentered trial. original data from 28 trial centers were published 1975 but inadequacies 1 center led recomputation these excluding the questionable results. Of 4031 patients remaining after exclusion 2033 control group and 1998 heparin-treated groups. 4.2% (n=170) died postoperatively overall: 94 among controls 76 group. Autopsies performed on 70.2% 65.7% patients. 21% (n=15) autopsied due actue massive whereas none subjects embolism. (P < .001). Data did not significantly alter total incidence deep-vein thrombosis nor bleeding complications observed both groups postoperatively.
sci-hub.se 参考文章(3)
U.F Gruber, R Fridrich, F Duckert, J Torhorst, J Rem, PREVENTION OF POSTOPERATIVE THROMBOEMBOLISM BY DEXTRAN 40, LOW DOSES OF HEPARIN, OR XANTINOL NICOTINATE The Lancet. ,vol. 309, pp. 207- 210 ,(1977) , 10.1016/S0140-6736(77)91011-X
Fridrich R, Gruber Uf, Duckert F, Rem J, Subcutaneous small heparin doses for the prevention of thrombosis in general surgery and urology Schweizerische Medizinische Wochenschrift. ,vol. 105, pp. 827- ,(1975)
V.V. Kakkar, LOW-DOSE HEPARIN The Lancet. ,vol. 309, pp. 659- ,(1977) , 10.1016/S0140-6736(77)92105-5