Particulate-Driven Type-2 Immunity and Allergic Responses

摘要: It is thought that particle pollutants exacerbate allergic responses are defined as highly increased airway cellular and IgE production. These particulates nanometer- to micrometer-sized particles such particulate matter 2.5 (PM2.5), diesel exhaust particles, Asian sand dust (ASD). Other than pollutants, with similar sizes aluminum salts (alum) silica also known induce type-2 immune characterized by the activation of eosinophils induction antigen-specific serum in vivo. All these have a common feature they function adjuvants promote responses. An adjuvant an activator innate immunity, immunity be required for adequate adaptive immunity. In general, cells activated through pattern recognition receptors (PRRs) Toll-like (TLRs) inflammatory However, basis adjuvanticity including mechanisms which elicit still unclear. addition, not all this review, we will discuss proposed behind activity their role exacerbation inflammation.