Guanine and plasmid DNA binding of mono- and trinuclear fac-[Re(CO)3]+ complexes with amino acid ligands.
作者： Fabio Zobi , Bernhard Spingler , Roger Alberto
关键词: Moiety 、 Rhenium 、 Stereochemistry 、 Amino acid 、 Nucleobase 、 DNA 、 Adduct 、 Chemistry 、 Guanine 、 In vitro
摘要: We have synthesized and fully characterized four new complexes comprising the fac-[Re(CO)3]+ moiety ligands NH3, L-proline (Pro), or N,N-dimethylglycine (dmGly). The reaction of [Re(H2O)3(CO)3]+ with two amino acids gives trinuclear general formula [Re(L)(CO)3]3 (where L = acid). studied in vitro behavior these compounds guanine DNA order to understand whether cytotoxicity exhibited by certain rhenium based on core is due formation nucleobase inter- intrastrand links between bases. performed model studies structural effects induced different rhenium(I) tricarbonyl PhiX174 plasmid electrophoretic methods. Our results show that available coordination sites interact form a stable adduct likely involve
core.ac.uk
uzh.ch
sci-hub.se 参考文章(56)
Sabrina Pacor, Gianni Sava, Valentina Ceschia, Francesca Bregant, Giovanni Mestroni, Enzo Alessio, Antineoplastic effects of mer-trichlorobisdimethylsulphoxideaminorutheniumIII against murine tumors: Comparison with cisplatin and with ImH[RuIm2Cl4] Chemico-Biological Interactions. ,vol. 78, pp. 223- 234 ,(1991) , 10.1016/0009-2797(91)90016-Z
Kay Severin, Ralph Bergs, Wolfgang Beck, Biometallorganische Chemie – Übergangsmetallkomplexe mit α‐Aminosäuren und Peptiden Angewandte Chemie. ,vol. 110, pp. 1722- 1743 ,(1998) , 10.1002/(SICI)1521-3757(19980619)110:12<1722::AID-ANGE1722>3.0.CO;2-N
Helen T. Chifotides, Karl M. Koshlap, Lisa M. Pérez, Kim R. Dunbar, Novel Binding Interactions of the DNA Fragment d(pGpG) Cross-Linked by the Antitumor Active Compound Tetrakis(μ-carboxylato)dirhodium(II,II) Journal of the American Chemical Society. ,vol. 125, pp. 10714- 10724 ,(2003) , 10.1021/JA0291585
Paul M. van Vliet, Sarinten M.S. Toekimin, Jaap G. Haasnoot, Jan Reedijk, Olga Nováková, Oldrich Vrána, Viktor Brabec, mer-[Ru(terpy)Cl3] (terpy = 2,2′:6′,2″-terpyridine) shows biological activity, forms interstrand cross-links in DNA and binds two guanine derivatives in a trans configuration Inorganica Chimica Acta. ,vol. 231, pp. 57- 64 ,(1995) , 10.1016/0020-1693(94)04320-U
William Bauer, Steven L. Gonias, Siu K. Kam, Kun C. Wu, Stephen J. Lippard, Binding of the antitumor drug platinum uracil blue to closed and nicked circular duplex DNAs Biochemistry. ,vol. 17, pp. 1060- 1068 ,(1978) , 10.1021/BI00599A019
J. L. Bear, C. L. Yao, L. M. Liu, F. J. Capdevielle, J. D. Korp, T. A. Albright, S. K. Kang, K. M. Kadish, Synthesis, molecular structure, and electrochemical properties of two geometric isomers of tetrakis(.mu.-2-anilinopyridinato)dirhodium complexes Inorganic Chemistry. ,vol. 28, pp. 1254- 1262 ,(1989) , 10.1021/IC00306A012
Gary L. Cohen, Jay A. Ledner, William R. Bauer, H. Michael Ushay, Carl Caravana, Stephen J. Lippard, Sequence dependent binding of cis-dichlorodiammineplatinum(II) to DNA Journal of the American Chemical Society. ,vol. 102, pp. 2487- 2488 ,(1980) , 10.1021/JA00527A072
Michael J. Clarke, Bruce Jansen, Kenneth A. Marx, Ray Kruger, Biochemical effects of binding [(H2O)(NH3)5RuII]2+ to DNA and oxidation to[(NH3)5RuIII]n—DNA. Inorganica Chimica Acta. ,vol. 124, pp. 13- 28 ,(1986) , 10.1016/S0020-1693(00)82080-0
Wenwu Wang, Yaw Kai Yan, T.S Andy Hor, Jagadese J Vittal, Jessica R Wheaton, Iris H Hall, Synthesis, X-ray structures, and cytotoxicity of rhenium(I) carbonyl 2-(dimethylamino)ethoxide complexes Polyhedron. ,vol. 21, pp. 1991- 1999 ,(2002) , 10.1016/S0277-5387(02)01045-8
Gennaro Esposito, Sabina Cauci, Federico Fogolari, Enzo Alessio, Marco Scocchi, Franco Quadrifoglio, Paolo Viglino, NMR structural characterization of the reaction product between d(GpG) and the octahedral antitumor complex trans-RuCl2(DMSO)4 Biochemistry. ,vol. 31, pp. 7094- 7103 ,(1992) , 10.1021/BI00146A010