G protein-coupled receptors for energy metabolites as new therapeutic targets.

作者: Clara C. Blad , Cong Tang , Stefan Offermanns

DOI: 10.1038/NRD3777

关键词: SecretionSense (molecular biology)HormoneReceptorBiochemistryHormone metabolismG protein-coupled receptorDiabetes mellitusKetone bodiesBiology

摘要: … Owing to their ability to bind to ligands with a high specificity and affinity, GPCRs are preferentially targeted for the development of new therapeutics and account for about 20% of the …

参考文章(253)
Semple G, Richman Jg, Boatman Pd, Recent progress in the discovery of niacin receptor agonists. Current Opinion in Drug Discovery & Development. ,vol. 10, pp. 452- 459 ,(2007)
John F. Paolini, Yale B. Mitchel, Robert Reyes, Uma Kher, Eseng Lai, Douglas J. Watson, Josephine M. Norquist, Alan G. Meehan, Harold E. Bays, Michael Davidson, Christie M. Ballantyne, Effects of Laropiprant on Nicotinic Acid-Induced Flushing in Patients With Dyslipidemia††A list of study investigators appears in the Appendix. The American Journal of Cardiology. ,vol. 101, pp. 625- 630 ,(2008) , 10.1016/J.AMJCARD.2007.10.023
William M. Oldham, Heidi E. Hamm, How do receptors activate G proteins Advances in Protein Chemistry. ,vol. 74, pp. 67- 93 ,(2007) , 10.1016/S0065-3233(07)74002-0
Ai-Dong Qi, T. Kendall Harden, Robert A. Nicholas, GPR80/99, proposed to be the P2Y15 receptor activated by adenosine and AMP, is not a P2Y receptor Purinergic Signalling. ,vol. 1, pp. 67- 74 ,(2004) , 10.1007/S11302-004-5069-0
Zachary Bloomgarden, Yehuda Handelsman, Did AIM-HIGH aim too low? Journal of Diabetes. ,vol. 4, pp. 1- 2 ,(2012) , 10.1111/J.1753-0407.2011.00176.X
Timo Wittenberger, Susanne Hellebrand, Antonia Munck, Hans-Jürgen Kreienkamp, H Chica Schaller, Wolfgang Hampe, GPR99, a new G protein-coupled receptor with homology to a new subgroup of nucleotide receptors. BMC Genomics. ,vol. 3, pp. 17- 17 ,(2002) , 10.1186/1471-2164-3-17
Zachary T. Bloomgarden, Andrew Drexler, Fibrate use in diabetes: new concepts. Journal of Diabetes. ,vol. 3, pp. 1- 2 ,(2011) , 10.1111/J.1753-0407.2010.00108.X
David L. Topping, Peter M. Clifton, Short-Chain Fatty Acids and Human Colonic Function: Roles of Resistant Starch and Nonstarch Polysaccharides Physiological Reviews. ,vol. 81, pp. 1031- 1064 ,(2001) , 10.1152/PHYSREV.2001.81.3.1031
Noriaki Hashimoto, Chisato Nakama, Yasuhiro Sasaki, Makoto Ishikawa, Novel phenyl-isoxazol-3-ol derivative ,(2007)