Invasive aspergillosis in patients with hematologic malignancies.

摘要: Invasive aspergillosis is an increasingly common and often fatal opportunistic fungal infection in patients with hematologic malignancies. Prolonged profound neutropenia remains a key risk factor for the development of invasive aspergillosis. However, qualitative deficiencies host immune responses resulting from prolonged corticosteroid therapy, graft-versus-host disease, cytomegalovirus are important factors recurrence progression Aspergillus infections after bone marrow recovery. Early diagnosis challenge, few tools available monitoring its course once established. Even recent introduction new antifungal therapies, mortality high, uniformly effective prophylaxis or preemptive therapeutic strategies lacking. Strategies such as combination therapy immunotherapy used first-line treatment approaches documented despite paucity clinical trial data. Recent advances our understanding epidemiology, pathogenesis, malignancies reviewed. The problems controversies associated defining optimal this heavily immunocompromised population highlighted.