10 – Diffuse Parenchymal Lung Diseases Associated with Known Etiologic Agents

摘要: A variety of known etiologic agents can cause diffuse parenchymal lung disease, also referred to as interstitial disease. These include inorganic dusts (the pneumoconioses), organic antigens hypersensitivity pneumonitis), drugs, and radiation the thorax. The most common disorders classified pneumoconioses silicosis, coal worker's pneumoconiosis, asbestosis, berylliosis. Some these involve toxicity to, or activation macrophages, whereas beryllium induces a reaction that clinically mimics sarcoidosis. Many induce pneumonitis, which have presentation ranging from an acute illness with transient pulmonary infiltrates chronic wide range drugs are now be associated important categories being cancer chemotherapeutic newer biological but number other miscellaneous been implicated. Finally, therapy directed thorax, commonly for breast cancer, Hodgkin inflammatory process in lungs (radiation pneumonitis) more fibrotic fibrosis).