TiO2-nanoparticles shield HPEKs against ZnO-induced genotoxicity
作者： Mustafa Hussain Kathawala , Zhao Yun , Justin Jang Hann Chu , Kee Woei Ng , Say Chye Joachim Loo
DOI: 10.1016/J.MATDES.2015.08.108
关键词: Genotoxicity 、 Tio2 nanoparticles 、 Nanomaterials 、 Oxidative stress 、 Biophysics 、 Nanoparticle 、 Materials science 、 Nanotechnology 、 DNA damage
摘要: Abstract Usage of sunscreens has become commonplace amongst outdoor sports. Recently, nanomaterials have gained increasing market share as ingredients in (as well other topically applied products). In particular ZnO and TiO2 nanoparticles (ZNP TNP) found their niche this application. This study investigated the safety aspects these from a combinatorial exposure point view. Focus was on investigating generation oxidative stress induction DNA damage which two caused. It that TNPs triggered stronger than ZNPs but remained more potent at causing damage. The individual mechanisms were to be through for (indirect genotoxicity) Zn2 + ion nuclear uptake resulting ZNP (direct genotoxicity). Interesting, it intracellular could adsorb ions lower turn shielding HPEKs ZNP-induced genotoxicity. Toxicological assessments dual nanoparticle systems remain an unstudied area based results obtained deserves further consideration.
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