Mechanism of proteinase complex formation with α2-macroglobulin: Three modes of trypsin binding

作者: Lars Sottrup-Jensen , Torben E. Petersen , Staffan Magnusson

DOI: 10.1016/0014-5793(81)81097-6

关键词: Mechanism (biology)DithiothreitolBiochemistryMacroglobulinKunitz STI protease inhibitorComplex formationChemistryChromatographyTrypsinPolyacrylamide gel electrophoresis

摘要:

参考文章(31)
B. Amand, F. Pochon, J. Bieth, D. Lavalette, Rotational relaxation of free and protease-bound alpha2-macroglobulin. Journal of Biological Chemistry. ,vol. 253, pp. 7496- 7499 ,(1978) , 10.1016/S0021-9258(17)34530-1
R B Sim, T M Twose, D S Paterson, E Sim, The covalent-binding reaction of complement component C3. Biochemical Journal. ,vol. 193, pp. 115- 127 ,(1981) , 10.1042/BJ1930115
R P Swenson, J B Howard, Structural characterization of human alpha2-macroglobulin subunits. Journal of Biological Chemistry. ,vol. 254, pp. 4452- 4456 ,(1979) , 10.1016/S0021-9258(17)30030-3
Lars Sottrup-Jensen, Peter B. Lønblad, Terrence M. Stepanik, Torben E. Petersen, Staffan Magnusson, Hans Jörnvall, Primary structure of the ‘bait’ region for proteinases in α2-macroglobulin: Nature of the complex FEBS Letters. ,vol. 127, pp. 167- 173 ,(1981) , 10.1016/0014-5793(81)80197-4
John T. Dunn, Robert G. Spiro, The α2-Macroglobulin of Human Plasma I. ISOLATION AND COMPOSITION Journal of Biological Chemistry. ,vol. 242, pp. 5549- 5555 ,(1967) , 10.1016/S0021-9258(18)99392-0
Robert Huber, Dietmar Kukla, Wolfram Bode, Peter Schwager, Klaus Bartels, Johann Deisenhofer, Wolfgang Steigemann, Structure of the complex formed by bovine trypsin and bovine pancreatic trypsin inhibitor: II. Crystallographic refinement at 1.9 Å resolution Journal of Molecular Biology. ,vol. 89, pp. 73- 101 ,(1974) , 10.1016/0022-2836(74)90163-6
P K Hall, R C Roberts, Physical and chemical properties of human plasma alpha2-macroglobulin. Biochemical Journal. ,vol. 173, pp. 27- 38 ,(1978) , 10.1042/BJ1730027
Zena Werb, Mary C. Burleigh, Alan J. Barrett, Phyllis M. Starkey, The interaction of α2-macroglobulin with proteinases. Binding and inhibition of mammalian collagenases and other metal proteinases Biochemical Journal. ,vol. 139, pp. 359- 368 ,(1974) , 10.1042/BJ1390359